妊高征患者血浆一氧化氮和内皮素变化以及对胎儿的影响

目的：探讨一氧化氮（ＮＯ）和内皮素（ＥＴ－１）在妊高征发病中的作用及其对胎儿生长发育的影响。方法：采用比色法和放射免疫法对正常妊娠妇女２７例，正常未孕组２０例９对照组），妊高征患者５２例（妊高征组）的血浆、新生儿脐血（２３例）中ＮＯ和ＥＴ－１水平进行检测。结果：妊高征组ＥＴ－１水平较对照组高，以中重度妊高征组增高显著（Ｐ〈０．０１）。ＮＯ水平较对照组低，差异有显著性（Ｐ〈０．０５）。在中重度妊高征者中，合并胎儿生长发育迟缓组（ＩＵＧＲ）母血和新生儿脐血ＥＴ－１水平明显高于 且。ＮＯ水平则明显低于未合并ＩＵＧＲ组。结论：ＮＯ的合成、释放减少与内皮细胞损伤ＥＴ－１释放增加，在妊高征发病中超重要作用。并且影响胎儿的生长发育。

Changes of plasma NO and ET- 1 levels with pregnancy iduced hypertension and influence of fetus development

Objective:To investigate the role of nitric oxide (NO)and endothelin(ET-1) in the pathogenesis of pregnancy induced hypertension(PIH) and influence of fetus development. Methods:In 52 cases of PIH the plasma concentration of ET-1 was measured by RIA,and NO was measured by colorinetry.27 normal pregnant women served as control group. Results:The levels of plasma ET-1 in patients with PIH were signitficantly higher htan those in healthy pregnancies (P<0.01).There was a positive correlation between the plasma ET-1 level and degree of PIH,the higher the ET-1 level,the severer the PIH,The levels of plasma NO in patients with moderate and severe PIH decreased singifcantly than those in healthy pregnancy (P<0.05),Umbilical blook ET-1 levels in PIH with intrauterine growth retardation(IUGR) were significantly higher than those in PIH without IUGR,however NO were decreased.Conclusion:Our study demonstrated and increase of ET-1 level and decread of NO level in maternal plasma with PIH the results may have an effect and the pathogenesis of PIH and fetal development.