降脂胶囊治疗高脂血症的临床观察

目的:观察降脂胶囊治疗高脂血症的降脂疗效和安全性,为其临床应用和开发提供科学依据。方法:按纳入标准选择2011年4-9月我院治未病中心高脂血症患者120例,随机分为治疗组和对照组,各60例。治疗组给予降脂胶囊,2 g/次(0.5 g/粒),餐后口服,bid;对照组60例给予洛伐他汀口服,1片/次(20 mg/片),qn。各组均连续治疗3个月,治疗期间避免服用影响血脂代谢的其他药物。观察各组患者治疗前后中医证候积分、血脂总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)水平的变化。结果:治疗3个月后,各组中医证候总积分均显著降低,且治疗组优于对照组(P<0.05);两组血清TC、TG、LDL-C水平显著降低,组间差异无统计学意义(P>0.05),两组血清HDL-C水平变化无统计学意义(P>0.05);治疗期间对照组有1例因氨基转移酶升高退出试验,治疗组未出现明显与该药物相关的不良反应。结论:降脂胶囊具有肯定的调脂作用,与洛伐他汀疗效相当,且安全性好,值得推广应用。

Observation on Clinical Efficacy of Antihyperlipidemia Capsules for Hyperlipidemia

Objective： To observe the clinical efficacy and safety of antihyperlipidemia capsules so as to provide a scientific basis for the clinical use and development of the drugs . Methods： According to the selection standard , 120 patients with hyperlipidemia were chosen from Preventive Treatment of Disease Center of our hospital during Apr . to Sep . of 2011 . They were divided into treatment and control groups randomly , 60 in every group . Patients in treatment group were given antihyperlipidemia capsules,2 g（0.5 g/pill） each time,2 times a day（po,after meal）. Those in control group were given lovastatin , 1 tablet （20 mg/tablet ） each time , qn . The medication lasted for 3 months . During the treatment , no other drugs which affect lipid metabolism were taken . The patients in each group were observed before and after treatment of TCM syndrome integral , total cholesterol （ TC ） , triglyceride （ TG ） , low density lipoprotein choles-terol （ LDL-C ） and high density lipoprotein cholesterol （ HDL-C ） levels . Results： After 3 month treatment , the TCM syndrome integral decreased significantly and the treatment group was better than control group （ P0 . 05 ） and the differences of HDL-C level of each group were not statistically significant （ P〉0 . 05 ） . A patient in control group withdrew from the study because of elevated aminotransferase . The treatment group had no obvious ad-verse reactions related to the drug . Conclusion： It was proved that antihyperlipidemia capsules had the effect of lipid regulating , its effectiveness is comparable with lovastatin , and good in safety and worthwhile for extensive application .