Interferon treatment for hepatitis B-associated membranous glomerulonephritis in two Chinese children |
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Authors: | Sik-Nin Wong Edwin C. L. Yu Anna S. F. Lok Kwok-Wah Chan Yu-Lung Lau |
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Affiliation: | (1) Department of Paediatrics, University of Hong Kong, Hong Kong;(2) Department of Medicine, University of Hong Kong, Hong Kong;(3) Department of Pathology, University of Hong Kong, Hong Kong;(4) Department of Paediatrics, Queen Mary Hospital, Pokfulam Road, Hong Kong |
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Abstract: | Two Chinese boys, aged 3.5 and 5 years, developed nephrotic syndrome and were chronic carriers of hepatitis B virus surface antigen (HBsAg) and hepatitis B virus e antigen (HBeAg). Renal biopsy showed membranous glomerulonephritis and liver biopsy showed chronic persistent hepatitis. They were given interferon--2a at a dose of 5 MU/m2 on alternate days for 12 and 16 weeks after 2 years of persistent nephrotic syndrome. Patient 1 showed complete remission and resolution of hepatosplenomegaly, but his serum remained positive for HBsAg, HBeAg and hepatitis B virus DNA. Patient 2 showed only a transient clinical response and seroconversion from HBeAg to anti-HBe status. Although not always successful, interferon treatment should be considered in severe persistent nephrotic states, since there is at present no satisfactory treatment for this form of glomerulonephropathy. |
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Keywords: | Membranous nephropathy Hepatitis B virus infection Interferon |
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