Association between non‐atopic hand eczema and interleukin‐13 gene polymorphism in Taiwanese nursing population |
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| Authors: | Yin‐Chun Chen Hung‐Pin Tu Ching‐Shuang Wu Ying‐Chin Ko Hsin‐Su Yu Yi‐Wei Lu Wan‐Chen Li Gwo‐Shing Chen Cheng‐Che E Lan |
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| Institution: | 1. Department of Dermatology, Kaohsiung Medical University Hospital, , Kaohsiung, Taiwan;2. Department of Dermatology, Center of Excellence of Environmental Medicine, College of Medicine, Kaohsiung Medical University, , Kaohsiung, Taiwan;3. Department of Dermatology, Kaohsiung Municipal Ta‐Tung Hospital, , Kaohsiung Medical University, Kaohsiung, Taiwan;4. Department of Public Health and Environmental Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, , Kaohsiung, Taiwan;5. Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, , Kaohsiung, Taiwan;6. Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, , Taichung, Taiwan |
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| Abstract: | Chronic hand eczema is an important occupational skin disease with atopic dermatitis (AD) and wet work being the most important risk factors. This study was launched to analyse the potential association between AD‐related inflammation genes and development of non‐atopic hand eczema among nurses in University Hospital. Atopic eczema, non‐atopic hand dermatitis and control groups were identified. The association between occurrence of non‐atopic hand eczema and interleukin (IL)‐13, IL‐4 and IL‐5 gene variants was analysed. IL13 rs20541 A allele assuming recessive model; odds ratio (OR) = 3.38, 95% CI: (1.63–7.00)] showed association with development of non‐atopic hand eczema. Additive score analyses showed combination of this gene variant with previously identified risk factors including certain SPINK5 polymorphism and more than 10 years of work experience conferred highest risk for development of non‐atopic hand eczema. As non‐atopic hand eczema made up significant portion of occupational skin diseases, further studies should be focused on this commonly encountered skin condition. |
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| Keywords: | atopic dermatitis interleukin‐13 non‐atopic hand eczema |
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