Expression and roles of Wilms' tumor 1‐associating protein in glioblastoma |
| |
| Authors: | Du‐Il Jin Sang Weon Lee Myoung‐Eun Han Hyun‐Jung Kim Seon‐Ae Seo Gi‐Yeong Hur Shin Jung Bong‐Seon Kim Sae‐Ock Oh |
| |
| Affiliation: | 1. Department of Anatomy, Pusan National University, , Yangsan, Korea;2. Department of Neurosurgery, Pusan National University, , Yangsan, Korea;3. Department of Medical Research Center for Ischemic Tissue Regeneration, Pusan National University, , Yangsan, Korea;4. Department of Forensic Medicine, School of Medicine, Pusan National University, , Yangsan, Korea;5. Department of Neurosurgery, Medical School, Chonnam National University, , Gwangju, Korea |
| |
| Abstract: | Glioblastoma is a diffusely growing malignant brain tumor and among the most aggressive of all tumors. Wilms' tumor 1‐associating protein (WTAP) is a nuclear protein that has been associated with regulation of proliferation and apoptosis. Although its dynamic expression and physiological functions in vascular cells have been reported, those in other cells are largely unknown. Here, we show for the first time that WTAP is overexpressed in glioblastoma. Moreover we found that WTAP regulates migration and invasion of glioblatoma cells. Specific knockdown by siRNA or overexpression by cDNA regulated migration and invasion of cancer cells. In xenograft study, WTAP overexpression made cancer cells more tumorigenic. In the investigation for its underlying mechanism, we found that the activity of epidermal growth factor receptor can be regulated by WTAP. These results reveal a novel function of WTAP and suggest its clinical application. |
| |
| Keywords: | |
|
|
