| 牙周塞治剂联合盐酸米诺环素软膏治疗兔牙周炎的动物实验观察 |
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| 引用本文： | 耿海霞,刘雪.牙周塞治剂联合盐酸米诺环素软膏治疗兔牙周炎的动物实验观察[J].广东牙病防治,2011,19(6):295-299. |
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| 作者姓名： | 耿海霞 刘雪 |
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| 作者单位： | 济宁医学院附属医院口腔科;济宁医学院口腔系; |
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| 摘 要： | 目的评价牙周塞治剂联合盐酸米诺环素软膏治疗动物实验性牙周炎的疗效。方法将48只日本大耳白兔随机分为4组,牙周炎未治疗组（C组）、牙周炎应用盐酸米诺环素组（M组）、牙周炎应用牙周塞治剂组（P组）、牙周炎应用盐酸米诺环素和牙周塞治剂组（MP组）,每组12只。在牙周炎模型建立成功后分别给予上述干预治疗,于1周、2周、4周分次对牙周组织行组织学观察,同时检查牙周探诊深度（probing depth,PD）和龈沟出血指数（sulcus bleeding index,SBI）。结果 4组用药前PD、SBI差异无统计学意义（P〉0.05）。M组1周、2周、4周时PD、SBI较基线时下降（P〈0.05）,1周、2周时PD、SBI小于C组,差异有统计学意义（P〈0.05）。P组仅在1周时SBI与C组有差异（P〈0.05）,2周、4周时PD、SBI与C组差异均无统计学意义（P〉0.05）。MP组1周、2周、4周时PD、SBI较基线时下降（P〈0.05）,且与C组比较差异有统计学意义（P〈0.05）。结论联合应用盐酸米诺环素软膏和牙周塞治剂后,大耳白兔牙周炎临床指标PD、SBI有改善。
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| 关 键 词： | 牙周炎 盐酸米诺环素 牙周塞治剂 动物实验 |
Therapeutic Effect of Periodontal Pack and Minocycline Hydrochloride on Rabbits Experimental Periodontitis |
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| GENG Hai-xia,LIU Xue.Therapeutic Effect of Periodontal Pack and Minocycline Hydrochloride on Rabbits Experimental Periodontitis[J].Journal of Dental Prevention and Treatment,2011,19(6):295-299. |
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| Authors: | GENG Hai-xia LIU Xue |
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| Institution: | GENG Hai-xia1,LIU Xue.1The Affiliated Hospital of Ji'ning Medical University,Ji'ning 272067,China |
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| Abstract: | Objective To evaluate the therapeutic effect of periodontal pack and minocycline hydrochloride on periodontitis in animal experiment.Methods Forty-eight rabbits were randomly divided into four groups,including control group(C group),minocycline hydrochloride group(M group),periodontal pack group(P group),minocycline hydrochloride combined periodontal pack group(MP group).Clinical parameters including probing depth(PD) and sulcus bleeding index(SBI) and periodontal tissue samples were compared after one week... |
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| Keywords: | Periodontitis Minocycline Periodontal pack Animal experiment |
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