Akt介导VEGF信号通路在促进胃癌淋巴管新生中的作用

随着研究的深入,肿瘤淋巴管新生已被证实在实体肿瘤淋巴转移途径中起着至关重要的作用,并可作为一个评价肿瘤预后的重要指标.但长期以来由于缺乏对淋巴管内皮特异因子和淋巴管检测技术的认识,对淋巴管转移具体机制与肿瘤淋巴管新生分子途径尚未完全明确.Akt信号通路是细胞内一条重要的信号传导通路,与肿瘤发生、增殖、抗凋亡、转移等密切相关.近年来发现Akt在介导VEGF信号通路与肿瘤淋巴管转移或肿瘤淋巴管新生的也存在着密切关系.本文对Akt信号通路在胃癌淋巴管新生中重要作用与研究进展作一综述.

Role of Akt-mediated VEGF signaling pathway in lymphangiogenesis in gastric cancer

Tumor lymphangiogenesis plays a vital role in lymphatic metastasis of solid tumors and is an important index for evaluation of prognosis. However, due to the lack of understanding of lymphatic endothelium-specific factors and the limitation of detection techniques, the specific mechanisms of lymphatic metastasis and molecule pathways involved in tumor lymphangiogenesis are not well understood. Akt signal pathway is an important transduction pathway that is closely related with the occurrence, proliferation, anti-apoptosis and metastasis of tumors. It has been found that Akt signaling has a close relationship with VEGF signal pathway and mediates lymphatic metastasis or tumor lymphangiogenesis. This article will summarize the role of Akt-mediated VEGF signaling pathway in lymphangiogenesis in gastric cancer.