| 粉防己碱对大鼠肺动脉高压影响的实验研究 |
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| 引用本文： | 亓峰,吴乃石. 粉防己碱对大鼠肺动脉高压影响的实验研究[J]. 黑龙江医学, 2010, 34(10): 737-741. DOI: 10.3969/j.issn.1004-5775.2010.10.007 |
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| 作者姓名： | 亓峰 吴乃石 |
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| 作者单位： | 哈尔滨医科大学附属第二医院心外科,黑龙江,哈尔滨,150086;哈尔滨医科大学附属第二医院心外科,黑龙江,哈尔滨,150086 |
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| 摘 要： | 目的探讨粉防己碱对肺动脉高压的治疗作用及其机制。方法 30只雄性Wistar大鼠随机分为3组,即:模型组、治疗组和对照组。采用左全肺切除及腹腔注射野百合碱建立大鼠肺动脉高压模型,应用粉防己碱灌胃干预治疗组。测定大鼠血液中NO的含量;血流动力学指标;右心指数;光镜下,观察肺小动脉病理变化。结果治疗组肺动脉压力降低,血液NO含量增高,右心指数降低。结论粉防己碱能够逆转大鼠肺血管重建,降低肺动脉压力。
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| 关 键 词： | 粉防己碱 肺动脉高压 一氧化氮 |
Experimental Study of Tetrandrine on Pulmonary Artery Hypertension in Rats |
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| QI Feng,WU Nai-shi. Experimental Study of Tetrandrine on Pulmonary Artery Hypertension in Rats[J]. Heilongjiang Medical Journal, 2010, 34(10): 737-741. DOI: 10.3969/j.issn.1004-5775.2010.10.007 |
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| Authors: | QI Feng WU Nai-shi |
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| Affiliation: | (The Second Affiliated Hospital of Harbin Medical University,Harbin 150086,CHINA) |
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| Abstract: | Objective To investigate the effect of tetrandrine（TET） on pulmonary hypertension in rats.Methods Thirty Wistar rats were randomly divided into 3 groups.To set up pulmonary hypertension model in rats.The TET was used to interfere the rats pulmonary hypertension model.The observed indexes included： mPAP、mRVP;mSAP;RV/LV＋S;pathological changes of right lung and blood NO.Results Group 1 Compared with Group 2,mPAP,mRVP,RV/LV＋S and blood NO were significantly different（P〈0.05） in Group 3.2 The histopathology showed that the lung vascular remodeling was reversed.Conclusion TET could decrease the pulmonary pressure and reversed the lung vascular remodeling.And this might be related to its effect of increasing the NO formed and released. |
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| Keywords: | Pulmonary artery hypertension（PAH） Tetrandrine（TET） Nitrogen monoxidum（NO） |
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