| 布洛芬口腔崩解片的制备及质量检查 |
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| 引用本文： | 龙晓英,杨帆,陈立豪,曹灼林.布洛芬口腔崩解片的制备及质量检查[J].中国医药工业杂志,2004,35(7):407-409. |
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| 作者姓名： | 龙晓英 杨帆 陈立豪 曹灼林 |
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| 作者单位： | 广东药学院药学系,广东,广州,510240 |
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| 摘 要： | 采用正交设计筛选布洛芬口腔崩解片的处方并考察片剂质量.所得优化处方为(%):交联羧甲纤维素钠6、枸橼酸0.5、吐温-80 0.02、香精2,氯化钠2、阿斯巴甜3、微粉硅胶1、硬脂酸镁0.5.所得片剂30s内完全崩解,3min释药80%以上,口感良好.
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| 关 键 词： | 布洛芬 口腔崩解片 质量评价 |
| 文章编号： | 1001-8255(2004)07-0407-03 |
Preparation and Quality of Ibuprofen Orally Disintegrating Tablets |
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| Authors: | LONG Xiao-Ying YANG Fan CHEN Li-Hao CAO Zuo-Lin |
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| Abstract: | The orthogonal design was used to optimize the formulation of ibuprofen orally disintegrating tablets, andquality of prepared tablets was examined. Besides ibuprofen, the tablets were composed of crosslinked carboxymethyl-cellulose sodium 6%, citric acid 0.5%, Tween-80 0.02%, essence 2%,chloride sodium 2%, aspartame 3%, colloidalsilicon dioxide 1%,magnesium stearate 0.5%. The prepared tablets disintegrated completely in 30s, dissolved more than80% in 3min and taste fine. |
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| Keywords: | ibuprofen orally disintegrating tablets quality evaluation |
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