两种大环内酯类抗生素治疗小儿支原体肺炎的成本-效果分析

目的:评价两种大环内酯类抗生素治疗小儿支原体肺炎(MMP)的疗效及成本。方法:选择浙江省临海市妇幼保健院小儿科MMP患儿120例,随机分为3组,采用不同方式治疗,A组为阿奇霉素静滴组,B组为红霉素静滴组,C组为红霉素-阿奇霉素序贯疗法。对3组疗效及成本-效果进行分析评价。结果:3组总有效率比较,C组与A组、B组差异无统计学意义(P>0.05);成本-效果比(C/E)及增量成本-效果比(△C/△E),C组最低。药价下降10%,3组成本-效果比(C/E)及增量成本-效果比(△C/△E),C组仍是最低。治疗过程中,A、B组出现不良反应,经对症处理后不良反应消失;C组无明显不良反应发生。3组不良反应发生率比较,差异有统计学意义(P<0.05)。结论:遵循安全、有效、经济的用药原则,红霉素-阿奇霉素序贯疗法最佳。

Cost-effective analysis of two different kinds of common macrolide antibiotics for the treatment of children with mycoplasma pneumonia

Objective:To evaluate the curative efifcacy and cost-effectiveness of two different kinds of macrolide antibiotics in the treatment of children with mycoplasma pneumonia (MPP).Methods:A total of 120 patients with MPP in the Department of pediatrics of our hospital were randomly divided into Group A, B and C. Patients in Group A, B and C were treated with azithromycin, erythromycin and erythromycin and azithromycin sequential therapy respectively. The curative efifcacy and cost-effectiveness of three groups were assessed. Results:The total effective ratio of three groups showed no signiifcant difference (P<0.05). Among cost-effective ratio and incremental cost-effective ratio of three groups, Group C was the lowest. When drug prices fell by 10%, cost-effectiveness ratio and the incremental cost-effectiveness ratio of three groups, Group C continued to be the lowest. There were cases with adverse reaction during treatment in Group A and B group which disappeared after symptomatic treatment.There was no case with obvious adverse reaction in Group C. There were signiifcant differences in the incidence rate of side effect among three groups(P<0.05).Conclusion: Following the principle of safe, effective and economic medication, erythromycin and azithromycin sequential therapy is the best.