增生性糖尿病视网膜病变患者房水中 VEGF与IL-6、IL-18相关性研究

目的研究增生性糖尿病视网膜病变（PDR）患者房水中血管内皮生长因子（VEGF）与白介素6（IL-6）、白介素18（IL-18）水平的差异，并探讨其之间的相关性。方法分析2013年1月至2014年6月75例我院收治的75例行白内障超声乳化手术的II型糖尿病患者的临床资料，观察组（39例）为PDP患者，对照组（36例）选取无糖尿病视网膜病变的患者。结果两组研究对象血清中总胆固醇（ TC）、甘油三酯（ TG）、高密度脂蛋白（ HDL-c）、低密度脂蛋白（LDL-c）水平均无统计学差异（ P ＞0．05），观察组患者血中糖化血红蛋白（HbA1c）水平明显高于对照组，差异具有统计学意义（ t ＝2．449， P ＜0．05）；观察组患者房水中IL-6（ t ＝16．14， P ＜0．001）、IL-18（ t ＝16.08， P ＜0．001）及VEGF（ t ＝5．361， P ＜0．001）水平明显高于对照组，差异具有统计学意义（ P ＜0．05）；观察组患者VEGF与IL-6（ r ＝0．815， P ＜0．001）、IL-18（ r ＝0．869， P ＜0．001）及HbA1c（ r ＝0．694， P ＜0．001）均呈现显著正相关。结论 VEGF、IL-6、IL-18、HbA1c在PDR的发生机制中起到了重要的作用，临床上可以用来作为治疗PDR患者的诊断参考指标。

Relationships between aqueous humor VEGF,IL-6, IL-18 levels and proliferative diabetic retinopathy

Objective To study aqueous humor levels of VEGF , IL-6, and IL-18 in patients with proliferative dia-betic retinopathy ( PDR) and to discuss the correlation of these cytokines to the disease .Methods Authors analyzed clini-cal data of totally 75 patients who received phacoemulsification in our hospital between January 2013 and June 2014 .There were 39 patients diagnosed with proliferative diabetic retinopathy , and other 36 patients were analyzed as control group .Re-sults There was no significant difference in serum TC , TG, HDL-c, LDL-c levels between the two groups .HbA1c was significantly higher in PDR patients ( t =2.449, P <0.05).Aqueous humor levels of IL-6 ( t =16.14, P <0.001), IL-18 ( t =16.08, P <0.001) and VEGF ( t =5.361, P <0.001) were also significantly higher in PDR patients . VEGF level was correlated to IL-6 ( r =0.815, P <0.001), IL-18 ( r =0.869, P <0.001), and HbA1c ( r =0.694, P <0.001).Conclusions VEGF, IL-6, IL-18 and HbA1c play important roles in the mechanism of PDR .They can be used as a clinical indicators of presence and progress of PDR .