替考拉宁临床应用合理性分析

目的:调查和分析临床应用替考拉宁的用药合理性,为替考拉宁的临床合理应用提供参考依据。方法:通过电子病历系统筛选2015年1月至12月期间使用替考拉宁的住院患者,提取患者临床资料并进行统计分析。结果:108例患者应用替考拉宁治疗,以肺部感染为主,占68.52%。病原学标本送检率达98.1%,送检样本阳性率为45.4%,根据细菌培养和药敏试验结果选用替考拉宁的37例(34.3%)。47例(43.5%)患者替考拉宁用药存在不合理之处,主要表现为未予起始负荷量(89.4%)、负荷剂量给药方案不合理(17.0%)以及未根据肾功能水平调整剂量(19.1%)等。结论:应继续规范替考拉宁的临床使用及给药方案,特别是负荷剂量及肾功能不全患者的剂量调整,提升替考拉宁合理使用水平。

Analysis on medication rationality of teicoplanin in clinical practices

Objective:This study is designed for surveying and analyzing medicaion rationality of teicoplanin in clinical practices in order to provide references for clinical rational use of teicoplanin.Methods: Inpatients using teicoplanin from January to December 2015 were screened using digital medical record system and included. Clinical data of included patients were extracted and analyzed.Results:108 cases were ifnally included in this study and the administration of teicoplanin in 68.5% cases were for the treatment of pulmonary infection. The submission test ratio of microbial specimens reached 98.1% while the positive ratio of microbial specimens was 45.4% and 37 cases (34.3%) adopted teicoplanin based on bacterial culture and antimicrobial susceptibility test. There were inappropriate usage of teicoplanin found in 47 cases (43.5%), including no loading dose (89.4%), incorrect loading dosing protocol (17.0%) and no adjustment according to renal function of patients (19.1%).Conclusion: Clinical use of teicoplanin and its dosing protocol should be further standarized in order to raise the rational use level of teicoplanin, especially in the aspect of loading dose and adjustment according to renal function of patients.