KAI1/CD82表达水平与肾母细胞瘤转移的相关性研究

目的探讨KA儿/CD82与肾母细胞瘤转移的相关关系。方法选取38例确诊为肾母细胞瘤的组织蜡块标本,按有无转移分为两组,采用免疫组织化学的方法检测KAI1/CD82的表达。结果肾母细胞瘤中无转移组和有淋巴结或远处转移组的KAI1/CD82阳性表达率分别为53.85%、33.33%,两者差异有统计学意义;Ⅰ、Ⅱ、Ⅲ、Ⅳ期肾母细胞瘤中,KAI1/CD82阳性表达率分别为62.50%、58.33%、33.33%、33.33%,各组间差异无统计学意义。无转移组和有淋巴结或远处转移组中,化疗组与未化疗组分别比较,差异均无统计学意义(P0.05)。结论肾母细胞瘤中KAI1/CD82的阳性表达率与肿瘤是否转移有关,与临床分期及术前是否化疗无关。

Relationship between KAI1/CD82 expression and metastasis of nephroblastoma

Objetive To explore the relationship between KAI1 /CD82 expression and metastasis of nephroblastoma. Methods The level of KAI1 /CD82 was detected by immunohistochemistry in 38 cases of nephroblastoma. Results The positive expression rates of nephroblastoma with and without metastasis were 53.85% and 33.33% respectively.It was statistically significant between two groups.The positive rates of KAI1 /CD82 inⅠ,Ⅱ,Ⅲ and Ⅳ stages were 62.50%,58.33%,33.33% and 33.33% respectively.No statis-tical significance existed between two groups.The differences of groups with and without chemotherapy were in-significant (P >0.05 ). Conclusions The positive rate of LAI1 /CD82 is correlated with metastasis in nephroblastoma while it has nothing to do with clinical stage or preoperative chemotherapy or not.