亚甲基四氢叶酸还原酶基因A1298C多态性与帕金森病易感性的Meta分析

目的探讨亚甲基四氢叶酸还原酶(MTHFR)基因A1298C位点单核苷酸多态性(SNP)与帕金森病(PD)易感性的关联情况。方法通过中国生物医学文献数据库、中国期刊网全文数据库、万方数据库、维普信息资源系统,Pub Med、Cochrane Library、Ovid SP、Wiley Online Library、Springer Link、EBSCO、Elsevier Science Direct、Google scholar数据库检索MTHFR基因A1298C位点SNP与PD相关的病例对照研究,利用Rev Man 5.3和Stata 12.0软件,根据异质性大小选用随机效应或固定效应模型对各研究数据进行分析。结果共纳入8篇文献。Meta分析结果提示PD组和对照组AA基因型OR=0.92,95%CI:0.78~1.09,P=0.33]和CC基因型OR=1.19,95%CI:0.89~1.59,P=0.23]、A等位基因OR=0.92,95%CI:0.81~1.04,P=0.19]和C等位基因OR=1.09,95%CI:0.96~1.24,P=0.19]差异均无统计学意义。结论 MTHFR基因A1298C位点SNP与PD易感性无关联性。

Meta-analysis on methlenetetrahydrofolate reductase gene polymorphisms and Parkinson's disease susceptibility

Objective To explore the association between A1298C polymorphism of methlenetetrahydrofolate reductase (MTHFR)gene and Parkinson's disease (PD)susceptibility.Methods The case-control studies of MTHFR gene and PD were selected from Chinese Biomedical Database,Chinese National Knowledge Infrastructure,Wanfang, Weipu,PubMed,Cochrane Library,OvidSP,Wiley Online Library,EBSCO,Elsevier Science Direct,Springer Link and Google scholar databases.The study data were analysed by random -effects or fixed -effects models depending on heter-ogeneity use RevMan 5.3 and Stata 12.0 software.Results Eight articles were included.The meta -analysis results suggested that there were no significant differences in genotype AAOR =0.92,95%CI:0.78 -1.09,P =0.33],geno-type CCOR =1.19,95%CI:0.89 -1.59,P =0.23],allele AOR =0.92,95%CI:0.81 -1.04,P =0.19]and al-lele COR =1.09,95%CI:0.96 -1.24,P =0.19]between PD group and control group.Conclusion No relationship is found between the A1298C polymorphism of MTHFR gene and PD susceptibility.