老年冠心病伴心力衰竭患者N末端钠尿肽前体和超敏C反应蛋白与左心室射血分数的相关性分析

目的观察和分析老年冠心病伴心力衰竭患者N末端钠尿肽前体(NT-pro BNP)和超敏C反应蛋白(hs-CRP)与左心室射血分数(LVEF)的相关性。方法选取100例老年冠心病伴心力衰竭患者作为研究组,选取50例健康老年人作为对照组,对所有研究对象的血浆NT-pro BNP水平、血清hs-CRP水平及LVEF水平进行检测和比较。结果研究组患者的血浆NT-pro BNP水平、血清hs-CRP水平均显著高于对照组而LVEF水平显著低于对照组(t=31.868、21.556、-14.361,P0.05),随着心功能分级的上升,患者的血浆NT-pro BNP水平、血清hs-CRP水平依次上升而LVEF水平依次下降(P0.05),老年冠心病伴心力衰竭患者的LVEF水平与血浆NT-pro BNP水平(标化回归系数=-0.637)、血清hs-CRP水平(标化回归系数=-0.824)均具有相关性(P0.05),老年冠心病伴心力衰竭患者的心功能分级与血浆NT-pro BNP水平(OR=1.753)、血清hs-CRP水平(OR=2.308)均具有相关性(P0.05)。结论血浆NT-pro BNP水平、血清hs-CRP水平升高是老年冠心病伴心力衰竭患者的典型表现,其水平与患者的LVEF和心功能分级具有相关性。

Correlationship between plasm N-terminal pro-B-type natriuretic peptide,high sensitive C reactive protein and left ventricular ejection fraction in the elderly patients with heart failure of coronary heart disease

Objective To observe and analyze the correlation between N -terminal pro -B -type natriuretic peptide (NT-proBNP),high sensitive C reactive protein (hs-CRP)and left ventricular ejection fraction (LVEF)in the elderly patients with heart failure of coronary heart disease.Methods One hundred cases of elderly patients with heart failure of coronary heart disease were selected as the study group,50 healthy elderly people were selected as the control group.The plasma NT-proBNP level,serum hs-CRP level and LVEF level of all objects were detected and compared.Re-sults The plasma NT-proBNP level and serum hs-CRP level of the study group were significantly higher than those in the control group while the LVEF level was significantly lower than that of the control group (t =31.868,21.556,-14.361,P <0.05).With the rising of heart function classification,the plasma NT-proBNP level and serum hs-CRP level were increased and LVEF level was decreased (P <0.05).The level of LVEF in elderly patients with heart failure of coronary heart disease was significantly correlated with plasma NT-proBNP level (standardized regression coefficient=-0.637),serum hs-CRP level (standardized regression coefficient =-0.824)(P <0.05).The heart function clas-sification in elderly patients with heart failure of coronary heart disease was significantly correlated with the plasma NT-proBNP level (OR =1.753),the serum hs-CRP level (OR =2.308)(P <0.05).Conclusions The elevated plasma NT-proBNP level and serum hs-CRP level are typically presents of elderly patients with heart failure of coronary heart disease,and they are correlated with LVEF and heart function classification.