| 前列腺癌组织中miR-21的表达及临床意义 |
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| 引用本文： | 张聪,曹立宇,尹玉,陈顺华,李玉洁.前列腺癌组织中miR-21的表达及临床意义[J].临床与实验病理学杂志,2016(12):1365-1367. |
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| 作者姓名： | 张聪 曹立宇 尹玉 陈顺华 李玉洁 |
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| 作者单位： | 安徽医科大学病理学教研室,合肥230032;安徽医科大学第一附属医院病理科,合肥230022 |
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| 基金项目： | 安徽省自然科学基金(KJ2013A150) |
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| 摘 要： | 目的探讨miR-21在前列腺癌组织中的表达及临床意义。方法采用原位分子杂交技术检测90例前列腺癌组织及69例良性前列腺增生组织中miR-21的表达,并复习相关文献。结果 miR-21在90例前列腺癌及69例良性前列腺增生中的阳性率分别为71.1%、24.6%。miR-21在前列腺癌组织中的表达明显高于良性前列腺增生组织(P0.05)。miR-21表达与Gleason评分有关(P0.05),与其他临床病理学因素无关。结论 miR-21在前列腺癌组织中表达上调,提示miR-21可能在前列腺癌的发生、发展过程中发挥重要作用。
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| 关 键 词： | 前列腺肿瘤 良性前列腺增生 miR-21 原位分子杂交 |
Expression of miR-21 in prostate cancer and its clinical significance |
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| Abstract: | Purpose To investigate the expression and clinical significance of microRNA-21 (miR-21) in patients with prostate cancer (PCa).Methods The human tissue specimens were paraffin-embedded blocks which were collected from the Department of Pathology.miR-21 was detected by in situ hybridization (ISH) in 90 cases of PCa and 69 cases of benign prostatic hyperplasia (BPH).Results The ISH data showed that the positive rate of miR-21 in PCa (71.1％) was significantly higher than that in BPH (24.6％) (P ＜ 0.05),the expression of miR-21 correlated with the Gleason grade (P ＜ 0.05),and no relationship was observed with other clinicpathological features (P ＞ 0.05).Conclusion The miR-21 plays an important role in the pathogenesis of PCa,which can be a new diagnostic target for PCa. |
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| Keywords: | prostate neoplasm benign prostatic hyperplasia miR-21 in situ hybridization |
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