Normal Values in Children for Myocardial Ultrasonic Tissue Characterization by Integrated Backscatter

Normal values in adults for ultrasonic tissue characterization by integrated backscatter have been reported previously and subsequently applied to patients with specific diseases. Factors influencing integrated backscatter values in a pediatric population are not clearly defined. To obtain normal values for myocardial ultrasonic integrated backscatter in a pediatric population, we studied 72 children with normal cardiac anatomy using an ultrasonic integrated backscatter imaging system. The parameters measured were at peak, nadir, and end-diastole in eight different regions with two different settings: fixed and variable. We subsequently calculated cyclic variation, the ratios of cyclic variation to end-diastole and to peak. Age ranged from 1 day to 17.4 years (median 4.4 years). More than 90% of data curves from the two regions in the left ventricular posterior wall in long-axis view had normal patterns, whereas more than 50% of curves for the other regions had abnormal patterns. Comparing the two posterior wall positions, there were no differences in cyclic variation between the two regions, with little effect of setting. Less effect of regions and settings was noted for the ratios of cyclic variation to end-diastole or peak. There was no relation between backscatter variables and age, gender, or height, and some variables correlated weakly with body surface area. The assessment of integrated backscatter in children is optimal with interrogation of the left ventricular posterior wall imaged in the long-axis view. More stable estimates are obtained when the cyclic variation is related to the peak or end-diastolic value.