大黄对烫伤后大鼠体内氧自由基的清除作用

目的：研究大黄对氧自由基的清除作用及其机制。方法：应用大鼠烫伤模型，采集小肠和肝脏标本，测定组织内谷胱甘肽过氧化物酶，过氧化物歧化酶和黄嘌呤氧化酶的活力。结果：烫伤后大鼠小肠和肝组织内ＧＳＨ－ＰＸ和ＳＯＤ大量消耗，而大黄治疗组大鼠上述组织的ＧＳＨ－ＰＸ和ＳＯＤ数量明显高于烫伤组，烫伤后小肠和肝脏内ＸＯ大量产生，大黄能明显降低小肠和肝组织内ＸＯ的产生。

Action of rhubarb on eliminating the oxygen free radicals from body of burned rats

Objective:To study the action of rhubarb on eliminating the oxygen free radical(OFR) and its mechanism.Methods:Rat burn model was used.The specimens of liver and small intestine were taken and the activities of glutathione peroxidase (GSHPx),superoxide dismutase (SOD),and xanthine oxidase (XO) in the above tissues were measured.Results:After burn the GSHPx and SOD in the liver and small intestine were largely consumed.However,in rhubarbtreated group they were significantly higher than those in burn group (all P <0 01).Furthermore,in burn group after burn XO in liver and small intestine was substantially produced and rhubarb could obviously reduce its production in tissues of liver and small intestine (all P <0 01).Conclusions:The rhubarb is able to decrease the production of OFR in the liver and small intestine after burns and the pharmaceutical mechanisms may be associated with reducing the production of XO in tissues.