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Molecular characterization of the glycoprotein genes of H5N1 influenza A viruses isolated in Israel and the Gaza Strip during 2006 outbreaks
Authors:Shimon Perk  Caroline Banet-Noach  Natalia Golender  Lubov Simanov  Ezra Rozenblut  Sagit Nagar  Shimon Pokamunski  Michael Pirak  Yevgenii Tendler  Maricarmen García  Alexander Panshin
Institution:(1) Division of Avian and Aquatic Diseases, Kimron Veterinary Institute, P.O.B. 12, Beit Dagan, 50250, Israel;(2) Poultry Veterinary Services, Beit Dagan, Israel;(3) Rambam Medical Center, Haifa, Israel;(4) Poultry Diagnostic and Research Center, College of Veterinary Medicine, The University of Georgia, Athens, GA, USA
Abstract:Highly pathogenic H5N1 avian influenza A viruses (AIV) have caused outbreaks among domestic poultry and wild aquatic birds in many Asian, European, and African countries since 1997. In March 2006 an avian H5N1 influenza A virus was isolated from poultry in Israel. In the present study we molecularly characterized the hemagglutinin (HA) and neuraminidase (NA) genes of eleven H5N1 viruses isolated from domestic poultry in Israel and Gaza in March–April 2006. Phylogenetic analysis of the HA and NA genes showed that the Israeli and Gazian viruses were closely related to viruses isolated in Egypt in 2006.
Keywords:H5N1 avian influenza virus  Hemagglutinin  Neuraminidase  Phylogenetic analysis
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