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| 补肾壮骨方药对骨转移癌疼痛大鼠痛行为及骨质破坏的影响 | |
| 引用本文： | 邓博,贾立群,高福云,潘琳.补肾壮骨方药对骨转移癌疼痛大鼠痛行为及骨质破坏的影响[J].国际中医中药杂志,2010,32(1). |
| 作者姓名： | 邓博 贾立群 高福云 潘琳 |
| 作者单位： | 1. 北京中医药大学,北京,100029 2. 中日友好医院中医肿瘤科,北京,100029 3. 中日友好医院临床研究所,北京,100029 |
| 摘 要： | 目的 探讨补肾壮骨方药对骨痛疼痛模型痛骨质破坏的治疗作用.方法 SD大鼠左后肢胫骨内接种MRMT-1细胞制成骨转移癌疼痛模型,给予补肾壮骨办约治疗.观察大鼠癌行为学改变,包括von Frey纤维刺激的50%缩足阈(50%PWT)和热刺激缩足潜伏期(TWL).对胫骨标本用HE染色观察病理形态学改变.结果 本研究采用骨癌疼痛模型出现肿瘤生长、骨质破坏和癌性骨痛等表现.相对于模型组,各中药治疗组50%PWT明显延长、TWL延长.病理形态学显示骨质破坏改普,肿瘤增殖减少.结论 补肾壮骨方药可有效治疗骨转移癌疼痛,抑制骨转移肿瘤灶,减轻骨转移所致的溶骨性骨质破坏. |
| 关 键 词： | 骨转移癌疼痛 补肾壮骨方 骨质破坏 |
Effects of herbal medicine extraction on bone destruction and pain behaviors in rats of bone cancer pain |
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| DENG Bo,JIA Li-qun,GAO Fu-yun,RAN Lin.Effects of herbal medicine extraction on bone destruction and pain behaviors in rats of bone cancer pain[J].International Journal of Traditional Chinese Medicine,2010,32(1). | |
| Authors: | DENG Bo JIA Li-qun GAO Fu-yun RAN Lin |
| Abstract: | Objective To evaluate therapeutic effects of Bushen-Zhuanggu medicine extraction on bone destruction in rats bone cancer pain.Methods Rat models of cancer-induced bone pain were established by inoculating MRMT-1 cells into tibia of rats.Behavioral signs indicative of pain including 50%paw withdrawal threshold(von Frey tactile sensitivity test)and thermal withdrawal latency were observed.Pathomorphological changes of tibia were monitored with HE staining.Results In the behavioral tests,herbal medicine treatment attenuated mechanical allodynia and thermal hyperalgesia.Histological examination showed that this treatment inhibited tumor proliferation and preserved the cortical and trabccular bone structure.Conclusion Bushen-Zhuanggu medicine extraction is an anti-nociceptive and bone-preserving agent in rats of bone cancer pain. |
| Keywords: | Bone cancer pain Bushen-Zhuanggu medicine extraction Bone destruction |
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