枸杞对小鼠辐射损伤后造血系统修复的促进作用

目的 探讨枸杞在小鼠辐射损伤后造血系统修复过程中的作用。方法 小鼠随机分为3组,正常对照组不做任何处理,喂饲正常饲料;另外2组,给予4.5 Gy照射后,喂饲正常饲料或添加枸杞的饲料,1个月后,处死小鼠,应用流式细胞仪分析外周血、脾脏、胸腺及骨髓中各种血细胞。结果 枸杞饲料组小鼠,外周血细胞总数及B细胞增多,骨髓细胞总数减少,骨髓前体B细胞及未成熟B细胞增多,造血干、祖细胞均显著减少。结论枸杞促进辐射损伤后造血干细胞动员及分化,加速造血系统的恢复。

Promoting effect of Lycium chinense Mill on hematopoietic reconstruction in mice after radiation injury

Objective To investigate the effect of Lycium chinense Mill on hematopoietic reconstruction in mice after radiation injury. Method Female C57BL/6J mice were grouped to 3 groups at random: the control group, with normal food and no treatment, and the other 2 groups, treated with 4.5 Gy irradiation, with normal food or food added with Lycium chinense Mill. After 1 month, the mice were sacrificed and analyzed the peripheral blood, spleen, thymus and bone marrow cells by flow cytometer. Results In the mice fed with Lycium chinense Mill, the percentage of B cells was increased in the peripheral blood, the pre-B and immature B cells were increased, too, and the percentage of hematopoietic stem/progenitor cells was decreased. Conclusion Lycium chinense Mill can promote the mobilization and differentiation of hematopoietic stem/progenitor cells, and accelerate the hematopoietic reconstruction after irradiation injury.