Antiproliferative cardenolides of an Elaeodendron sp. from the Madagascar rain forest(1) |
| |
Authors: | Cao Shugeng Brodie Peggy J Miller James S Ratovoson Fidy Callmander Martin W Randrianasolo Sennen Rakotobe Etienne Rasamison Vincent E Suh Edward M TenDyke Karen Kingston David G I |
| |
Affiliation: | Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA. |
| |
Abstract: | Bioassay-guided fractionation of an ethanol extract obtained from the Madagascar plant Elaeodendron sp. led to the isolation of two new cardenolides, elaeodendrosides T and U (1 and 2). The structures of the new compounds were elucidated using 1D and 2D NMR experiments and mass spectrometry. Compounds 1, 3, 4, and 5 showed significant antiproliferative activity against A2780 human ovarian cancer cells with IC50 values of 0.085, 0.019, 0.19, and 0.10 microM, respectively, while compounds 2 and 6 were less active. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|