| Studies on the antinociception effect of melatonin and its mechanism in the rat |
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| 引用本文： | Li Shu - hui Hu De - yao Li Xiao - hui Wang Zheng - guo. Studies on the antinociception effect of melatonin and its mechanism in the rat[J]. 中国药理通讯, 2005, 22(4): 52-52 |
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| 作者姓名： | Li Shu - hui Hu De - yao Li Xiao - hui Wang Zheng - guo |
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| 作者单位： | [1]Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, People＇s Republic of China [2]Faculty of Basic Medicine, Third Military Medical University, Chongqing 40003 |
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| 摘 要： | The antinociception effect of melatonin（Mel） and its mechanisms were studied on the trauma- pain model in the rat. A trauma - pain model was established in Wistar rats by combining right - hind limb amputation with 50℃ tail - flick test. The effects of Mel on central sensitization were studied through measuring the changes of the expression of c - fos （ an indicator of nociceptive transmission at the spinal level ） , subtance P（SP） and brain - derived neurotrophic factor （BDNF） in the spinal cord using immunohistochemistry. In addition, the contents of nitric oxide （NO） in brain and spinal tissues were also observed. The results showed that the immunoreactivity of BDNF and c - fos in spinal dorsal horn in injuried rats began to increase at the first day,
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| 关 键 词： | 褪黑激素 创伤 小鼠 动物实验 药理作用 |
Studies on the antinociception effect of melatonin and its mechanism in the rat |
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| Li;Shu;-;hui;Hu;De;-;yao;Li;Xiao;-;hui;Wang;Zheng;-;guo. Studies on the antinociception effect of melatonin and its mechanism in the rat[J]. , 2005, 22(4): 52-52 |
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| Authors: | Li Shu - hui Hu De - yao Li Xiao - hui Wang Zheng - guo |
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| Abstract: | |
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| Keywords: | Melatonin Trauma pain model Antinociceptive mechanism central sensitization, c - fos SP BDNF NO immunoreactivity |
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