| IDH1、ERCC1和MGMT在脑胶质瘤组织中的表达及意义 |
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| 引用本文： | 高超,王佳,梁振,孟庆印,.IDH1、ERCC1和MGMT在脑胶质瘤组织中的表达及意义[J].中国医学工程,2014(5):9-10. |
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| 作者姓名： | 高超 王佳 梁振 孟庆印 |
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| 作者单位： | [1]山东省汶上县人民医院神经外科,山东济宁272500; [2]华北石油公司总医院神经外科,河北任丘062552; [3]河南省肿瘤医院神经外科,河南郑州450003; [4]云南省肿瘤医院病理科,云南昆明650118 |
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| 摘 要： | 目的研究IDH1、ERCC1和MGMT在脑胶质瘤组织中的表达及其相关性。方法运用免疫组织化学法观察84例胶质瘤IDH1、ERCC1和MGMT的表达。结果 IDH1和ERCC1在胶质瘤细胞中表达随病理级别增加而升高,差异有统计学意义,IDH1在胶质瘤样本中的表达分别与ERCC1和MGMT有相关性,而ERCC1和MGMT之间无相关性。结论IDH1、ERCC1的检测可判断胶质瘤恶性程度,并可以将其作为判断预后的重要指标,检测ERCC1和MGMT可针对性选用化疗药物,对制定个性化化疗方案有重要参考价值。
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| 关 键 词： | 脑胶质瘤 IDH1 ERCC1 MGMT 免疫组织化学 |
Expression and clinical significance of IDH1,ERCC 1,MGMT in brain glioma |
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| Institution: | GAO Chao, WANG Jia, LIANG Zhen, et al (1.Wenshang People＇s Hospital,Jining, Shandong 272500,P.R.China;2.The General Hospital of Huabei Petroleum Administration Bureau,Renqiu,Hebei 062552,P.R.China;3.Henan Cancer Hospital,Zhenozhou, Henan 450003,P.R.China) |
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| Abstract: | Objective ] To investigate the expression and relationship of IDHI,ERCCI and MGMT in brain glioma. Methods ] lmnnmohistochemical stains were used to investigate the expression of IDH I,ERCCI and MGMT in 84 cases of brain glioma. Results ] It was statistical significance of the expression of IDH1 and ERCCI in brain glioma increased with pathological grade rise.There was a correlation between IDH 1 and ERCC 1 or MGMT,and was not a correlation between ERCCI and MGMT in 84 cases of brain glioma. Conclusion ] IDH1 and ERCC1 could be used as two indexes to define the degree of brain glioma,and as important indexes for prognosis.The chemotherapy drugs was well-targeted choiced under the guidance of ERCC 1 and MGMT.It was important reference value for personalized chemotherapy. |
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| Keywords: | brain glioma IDH1 ERCC 1 MGMTI mmunohistochemistry |
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