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Application of derivative spectrophotometry for determination of coenzyme Q10 in pharmaceuticals and plasma |
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| Authors: | Joanna Karpińska Bo?ena Miko?u? Janina Piotrowska-Jastrz?bska |
| Affiliation: | aUniversity in Bia?ystok (former Warsaw University, Bia?ystock Branch), J. Pi?sudskiego 11/4, 15-447 Bia?ystok, Poland;bDepartment of Pediatric Propedeutic, Medical Academy of Bia?ystok, J. Waszyngtona 17, 15-274 Bia?ystok, Poland |
| Abstract: | The use of derivative spectrophotometry is proposed in this work for determination of coenzyme Q10 in formulations and in human plasma. The spectrophotometric procedure is simpler and less expensive than chromatographic techniques commonly used for the analysis of coenzyme. The active compound can be determined in the range 0.25–10 ppm for standard solutions and pharmaceuticals and 0.05–1.5 ppm in plasma. The proposed method was applied for coenzyme determination in real samples. The results agree well with declared value and with these obtained by HPLC. |
| Keywords: | Derivative spectrophotometry Coenzyme Q10 analysis Savitzky-Golay algorithm |
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