| 鼠疫活菌苗接种后人群血清学反应及动物自动保护力试验 |
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| 引用本文： | 孙成全 李佩霞. 鼠疫活菌苗接种后人群血清学反应及动物自动保护力试验[J]. 地方病通报, 1990, 5(1): 23-28 |
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| 作者姓名： | 孙成全 李佩霞 |
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| 作者单位： | 甘肃中医学院(孙成全，刘钟铮，陈翠洁)，兰州生物制品研究所(李佩霞)，甘肃省地方病研究所(崔景和)，甘肃省会宁601站(李涛)，长春生物制品研究所(张静华) |
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| 摘 要： | 以微量被动血凝方法,观测了两组人群用冻干鼠疫活菌苗(EV活菌苗)皮上划痕免疫后的抗体变化以及对豚鼠皮上接种后的保护力试验。经EV活菌苗皮上接种后,人群血清阳转率约80～90％,血凝试验抗体滴度持续时间不长,接种后15天抗体滴度最高,1个月后逐渐下降。但动物试验显示在免疫后的6个月内具有一定的免疫力。EV活菌苗皮上接种易被群众接受,剂量以15亿个菌可靠性大。
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| 关 键 词： | 鼠疫活菌苗 免疫性 人 动物实验 |
Serologic Response in Human and Active Pretection in Animals Induced by Inoculation of Live Y. pestis |
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| Sun Cheng-quan,. Serologic Response in Human and Active Pretection in Animals Induced by Inoculation of Live Y. pestis[J]. Endemic Diseases Bulletin, 1990, 5(1): 23-28 |
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| Authors: | Sun Cheng-quan |
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| Abstract: | Antibody response in human and active pretection in guinea-pigs were determined by microagglutination test. Results showed that, after scarification with live Y. pestis, antibody positive rates were 80%-90% in human sera for a short period of lime with peak tilers on day 15 and declined gradually in a month. In animal experiment, however, prelection was still found after inoculation for 6 months. Inoculation by scarification wilh live Y. pestis is a simple method but requires a large dose. |
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| Keywords: | Live vaccine. Yersinu pestis: Immunity Human Animal experiment Guinea Pig |
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