| 大黄酸及其衍生物的生物活性研究进展 |
| |
| 引用本文： | 余佳,吴晓晴,孙海峰,吉民. 大黄酸及其衍生物的生物活性研究进展[J]. 药学与临床研究, 2008, 16(2): 125-128 |
| |
| 作者姓名： | 余佳 吴晓晴 孙海峰 吉民 |
| |
| 作者单位： | 东南大学化学化工学院制药工程研究所,南京,210009;东南大学化学化工学院制药工程研究所,南京,210009;东南大学化学化工学院制药工程研究所,南京,210009;东南大学化学化工学院制药工程研究所,南京,210009 |
| |
| 摘 要： | 大黄酸是中药大黄的主要成分之一,临床可用于治疗骨关节炎、糖尿病肾病等疾病,并且具有协同抗肿瘤的作用.本文综述了大黄酸在抗炎、抗肿瘤等方面的药理活性及作用机制,并讨论了其母核取代的衍生物、氧杂蒽醌的类似物和酯衍生物的生物活性.
|
| 关 键 词： | 大黄酸 双乙酰大黄酸 骨关节炎 糖尿病肾病 结构修饰 |
| 文章编号： | 1673-7806(2008)02-125-04 |
| 收稿时间： | 2008-01-18 |
| 修稿时间： | 2008-01-18 |
Advance of biological activity of rhein and its derivatives |
| |
| YU Ji,WU Xiao-qing,SUN Hai-feng and JI Min. Advance of biological activity of rhein and its derivatives[J]. Pharmacertical and Clinical Research, 2008, 16(2): 125-128 |
| |
| Authors: | YU Ji WU Xiao-qing SUN Hai-feng JI Min |
| |
| Affiliation: | Institute of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210009, China;Institute of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210009, China;Institute of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210009, China;Institute of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210009, China |
| |
| Abstract: | Rhein, a main constituent of rhubarb, is a well-characterized anti-inflammatory agent with recognized utility in a range of inflammatory diseases such as ostarthritis, diabetic nephropathy etc. The resent studies on its pharmacological action, including anti-inflammatory, anti-tumor and so on, and its acting mechanisms were reviewed. And the biological activity of its derivatives, quinone and xanthone analogs and ester derivatives, was also discussed. |
| |
| Keywords: | Rhein Diacerhein Ostarthritis Diabetic nephropathy Chemical modification |
| 本文献已被 维普 万方数据 等数据库收录！ |
| 点击此处可从《药学与临床研究》浏览原始摘要信息 |
|
点击此处可从《药学与临床研究》下载全文 |
|
