甲状腺功能减退症患者血清瘦素水平与颈动脉内膜中层厚度及其相关性研究周卫东

摘要目的探讨甲状腺功能减退症患者血清瘦素（Lep）水平与颈动脉内膜中层厚度（IMT）及其相关性。方法选取甲减患者96例，设为甲减组；另选取健康体检合格者60例，设为时照组。检测两组受试者的血脂、甲状腺激素及Lep水平，超声检测颈动脉IMT，分析甲减患者血清Lep与颈动脉IMT的相关性。结果甲减组FT3、FT4低于对照组，TSH、TG、TC以及Lep、IMT均高于对照组（P〈0．0l或P〈0．05）。动脉弱样硬化（As）组与非As组血清Lep水平为（19．68±5．15）μg／L、（11．23±4．17）gg／L，差异具有统计学意义（P〈0．05）。Pearson相关分析显示甲减组患者血清Lep与FT3呈负相关，与IMT呈正相关（P〈0．01）；而与FT4、TSH、TG、TC无相关关系（P〉0．05）。结论甲减患者血清Lep水平、颈动脉IMT均高于正常水平，血清Lep与FT3负相关，与颈动脉IMT正相关，这提示Lep参与了As的发生发展。

Study on the serum leptin level and carotid artery intima-media thickness in patients with hypothy- roidism and correlation analysis

Objective To explorer the serum leptin （Lep） level and carotid artery intima-media thickness （IMT） in patients with hypothyroidism and the correlation between the indicators. Methods 96 cases with hypothyroidism were selected, and set as hypothyroidism group. 60 healthy volunteers with physical examination were selected as control group. Two groups＇ serum lipids, thyroid hormone and Lep were detected, and carotid artery IMT were detected by ultrasonic, also hypothyroidism pa- tients＇ correlation between serum Lep and carotid artery IMT were analyzed. Results Hypothyroidism group＇s serum FT~ and FT4 were lower than those in control group, and serum TSH, TG, TC, Lep and IMT were higher than those in control group （P〈0.01or P〈0.05）. Serum Lep in As group and non-As group were （19.68＋_5.15） stg/L and （11.23：J：4.17） ~g/L, and there was statistical differ- ence （P〈0.05）. Pearson correlation analysis showed that there was negative correlation with serum Lep and FT3, and positive correlation with serum Lep and IMT （P〈0.01）, yet there were no correla- tion between FT4, TSH, TG, TC with serum Lep （P〉0.05）. Conclusion Hypothyroidism patients＇ serum Lep and carotid artery IMT are both higher than normal level, and the serum Lep is negatively correlated with FT3, yet is positively correlated with carotid artery IMT, so it suggests that serum Lep is involved in As＇ occurrence and development in hypothyroidism.