大肠癌及癌旁粘膜c-erbB-2表达 |
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引用本文: | 彭敦发,林鸿民.大肠癌及癌旁粘膜c-erbB-2表达[J].皖南医学院学报,1996,15(3):189-191. |
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作者姓名: | 彭敦发 林鸿民 |
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摘 要: | 应用免疫组织化学S-P法检测了71例大肠癌及癌旁粘膜中原癌基因c-erbB-2蛋白的表达,结果表明,52.11%(37/71)大肠癌及12.5%(6/48)癌旁移行粘膜中c-erbB-2呈阳性表达,且32.4%(23/71)的大肠癌呈现(++)或(+++)的阳性或强阳性表达,而正常肠粘膜均为阴性。大肠癌c-erB-2表达与病人性别、年龄、肿瘤大小、部位,组织学类型、分化程度、浸润范围、淋巴结转移及Dukes分期等临床病理因素均无关。
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关 键 词: | 大肠癌 c-erbB-2 肿瘤基因 免疫组织化学 |
EXPRESSION OF c-erbB-2 ONCOPROTEIN IN COLORECTAL CARCINOMAS AND PARACANCEROUS MUCOSAS |
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Abstract: | We studied the expression of c-erbB-2 oncoprotein in 71 colorectal carcinomas and 48 paracancerous mucosas adjacent to the cancers by using S-P immunohistochemistry.We found that 52.11%(37/71) of cancers and 12.5%(6/48) of paracancerous mucosas presented positive expression of c-erbB-2 protein,whereas all normal mucosas were negative.There were no relationships being found between the expression of c-erbB-2 oncoprotein and tumor histology, tumor differentiation,lymph node metastasis and Dukes stage.It is suggested that over-expression of c-erbB-2 oncogene may take an important role in colorectal tumorigenesis. |
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Keywords: | colorectal neoplasms oncogenes c-erbB-2 immunohistochemistry |
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