| CYP1B1 432C/G基因多态性与子宫内膜异位症易感性的相关研究 |
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| 引用本文： | 陈茜,王玉凤,宗利丽.CYP1B1 432C/G基因多态性与子宫内膜异位症易感性的相关研究[J].昆明医学院学报,2012,33(7):21-23. |
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| 作者姓名： | 陈茜 王玉凤 宗利丽 |
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| 作者单位： | 1. 广州市红十字会医院、暨南大学医学院第四附属医院妇产科,广东广州,510220
2. 南方医科大学中医药学院中西医结合医院妇产科,广东广州,510315 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 目的探讨中国南方汉族妇女CYP1B1基因第3外显子432C/G(rs1056836)位点单核苷酸多态性(single nucleotide polymorphism,SNP)与子宫内膜异位症(endometriosis,Ems)遗传易感性的相关性.方法收集经手术证实的432例Ems患者和499例对照人群外周血,采用荧光定量PCR为基础的高分辨率熔解曲线分析(high resolution melting,HRM)技术检测CYP1B1 432C/G基因SNP.结果病例组和对照组妇女CYP1B1 432C/G位点CC、CG、GG基因型频率分别为80.6%、18.8%、0.7%以及77.6%、21.0%、1.4%,2组的基因频率分布差异无统计学意义(P>0.376);C和G等位基因分布为89.8%、10.1%以及88.1%、11.9%,2组差异无统计学意义(P>0.376).结论中国南方汉族妇女CYP1B1 432C/G位点SNP与Ems遗传易感性无明显相关性.
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| 关 键 词： | 子宫内膜异位症 细胞色素P4501B1 单核苷酸多态性 高分辨率熔解曲线分析 |
Association of the CYP1B1 432C/G Gene Polymorphism with Susceptibility to Endometriosis |
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| CHEN Qian
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WANG Yu-feng
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ZONG Li-li.Association of the CYP1B1 432C/G Gene Polymorphism with Susceptibility to Endometriosis[J].Journal of Kunming Medical College,2012,33(7):21-23. |
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| Authors: | CHEN Qian WANG Yu-feng ZONG Li-li |
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| Institution: | 1)Dept.of Gynecology and Obstetrics,Guangzhou Red Cross Hospital,The Fourth Affiliated Hospital of Medical College of Jinan University,Guangzhou Guangdong 510220;2)Dept.of Gynecology and Obstetrics,Hospital of Integrated Traditional Chinese Medicine and Western Medicine,School of Traditional Chinese Medicine,Southern Medical University,Guangzhou Guangdong 510315,China.) |
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| Abstract: | Objective To investigate the association of cytochrome P450 1B1 in exon 3 codon 432(C→G)(rs1056836)single nucleotide polymorphism(SNP)with the genetic susceptibility to endometriosis(Ems) in south Han Chinese women.Methods A case-control study was performed in 432 Ems patients and 499 control women to evaluate the SNP of CYP1B1 432C/G by using a fluorescent quantitative PCR-based high resolution melting(HRM)method.Results The frequencies of genotypes CC,CG,GG and two alleles CG in controls(77.6%,21.0%,1.4%,88.1% and 11.9%)were not significantly different from those in patients with endometriosis(80.6%,18.8%,0.7%,89.8% and 10.1%).Conclusion There is no significant association between the SNP of CYP1B1 432C/G and genetic susceptibility to Ems in south Han Chinese women. |
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| Keywords: | Endometriosis Cytochrome P450 1B1 Single nucleotide polymorphism High resolution melting curve |
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