| 5-氨基-3-乙酰丙酸光动力疗法在肿瘤诊断和治疗中的应用进展 |
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| 引用本文： | 赵转霞,屠璐,刘哲鹏. 5-氨基-3-乙酰丙酸光动力疗法在肿瘤诊断和治疗中的应用进展[J]. 药学服务与研究, 2014, 0(3): 188-191 |
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| 作者姓名： | 赵转霞 屠璐 刘哲鹏 |
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| 作者单位： | 上海理工大学医疗器械与食品学院药物制剂设备与工艺研究所,上海200093 |
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| 摘 要： | 5-氨基-3-乙酰丙酸（5-aminolevulinic acid,5-ALA）是一种内源性的光敏剂,肿瘤细胞和其他恶性细胞可以选择性地吸收外源性5-ALA,使细胞内积聚过量的原卟啉。原卟啉在一定波长的光照射下,发生化学反应,使肿瘤细胞或其他增生活跃的细胞坏死、凋亡,这一过程被称为氨基-3-乙酰丙酸-光动力疗法（aminolevulinic acid-photodynamic therapy,ALA-PDT）。本文对ALA-PDT近年来在肿瘤的诊断和治疗中的应用进展作一综述。
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| 关 键 词： | 5-氨基3乙酰丙酸 肿瘤 光动力疗法 综述 |
Advances of 5-aminolevulinic acid photodynamic therapy in diagnosis and treatment of tumors |
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| ZHAO ZhuanXia,TU Lu,LIU ZhePeng. Advances of 5-aminolevulinic acid photodynamic therapy in diagnosis and treatment of tumors[J]. Pharmaceutical Care and Research, 2014, 0(3): 188-191 |
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| Authors: | ZHAO ZhuanXia TU Lu LIU ZhePeng |
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| Affiliation: | [Institute of Pharmaceutical Preparations (Equipment ＆ Technology), School of Medical Instrument and Food Engineering, University of Shanghai for Seience and Technology, Shanghai 200093, China2 |
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| Abstract: | 5-aminolevulinic acid （5 ALA） is an endogenous photosensitizer, and exogenous 5-ALA can be absorbed selectively by tumor cells and other malignant cells, resulting in excessive accumulation of protoporphyrin in the cells. Chemical reactions took place when a certain wavelength of light irradiates, causing necrosis and apoptosis of tumor cells or other active proliferation cells. This process is called aminolevulinic acid-photodynamie therapy （ALA-PDT）. This paper is a review on the advances of ALA-PDT in the diagnosis and the treatment of tumors. |
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| Keywords: | 5-aminolevulinic acid neoplasm photodynamic therapy review |
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