Experimental stereotactic irradiation of normal rabbit lung: computed tomographic analysis of radiation injury and the histopathological features |
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Authors: | Kawase Takatsugu Kunieda Etsuo Deloar Hossain M Seki Satoshi Sugawara Akitomo Tsunoo Takanori Ogawa Eileen N Ishizaka Akitoshi Kameyama Kaori Takeda Atsuya Kubo Atsushi |
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Institution: | (1) Department of Radiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan;(2) CREST, Japan Science and Technology Agency, Tokyo, Japan;(3) Oncology Service, Medical Physics and Bioengineering Department, Christchurch Hospital, Christchurch, New Zealand;(4) Department of Anesthesiology, Keio University School of Medicine, Tokyo, Japan;(5) Department of Medicine, Keio University School of Medicine, Tokyo, Japan;(6) Division of Diagnostic Pathology, Keio University School of Medicine, Tokyo, Japan;(7) Radiotherapy Department, Ofuna Chuuo General Hospital, Kanagawa, Japan |
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Abstract: | Purpose The aim of this study was to establish an animal experimental model of pulmonary stereotactic irradiation and clarify the
morphological patterns of pulmonary radiation injury with computed tomography and the histopathological features.
Materials and methods Tiny spherical regions in the lungs of seven anesthetized rabbits were irradiated stereotactically with a single fractional
dose of 21–60 Gy. Subsequently, the irradiated lungs were observed biweekly with computed tomography (CT) for 24 weeks. Radiation
injury of the lung was examined histopathologically in one specimen.
Results Localized hypodense changes were observed 7–15 weeks after irradiation in three rabbits irradiated with 60 Gy, and the findings
persisted beyond that time. The electron density ratios in the lung fields obtained from the CT images were shown to be decreasing,
corresponding to the hypodensity changes. No clear increased density opacity was observed in any rabbit in the 60-Gy irradiated
group. Severe localized fibrotic change was observed in the histopathological specimens.
Conclusion Specific localized hypodensity changes were found in only three rabbits irradiated with 60 Gy, the highest dose we employed. |
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Keywords: | Stereotactic radiotherapy Rabbit Lung Computed tomography Radiation injury |
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