抗人白细胞介素8单克隆抗体乳膏治疗湿疹的随机双盲对照临床试验

目的：评价抗人白细胞介素8(IL-8)单克隆抗体乳膏治疗湿疹的疗效及安全性。方法：以乳膏基质为对照,对64例湿疹病人进行随机双盲用药,试验组32例,对照组32例,每日早晚各外用1次,连续3 wk,观察其疗效和不良反应。结果：经过3 wk治疗,试验组和对照组痊愈率分别为25%和3%,有效率分别为47%和9%,临床疗效2组差异有显著意义(P＜0.05),试验组优于对照组,2组不良反应发生率相似(P＞0.05)。结论：抗人IL-8单克隆抗体乳膏治疗湿疹安全、有效。

A double blind randomized controlled clinical trial of antihuman interleukin-8 monoclonal antibody cream in treatment of eczema

AIM:To evaluate the efficacy and safety of antihuman interleukin-8 monoclonal antibody(IL- 8)cream in the treatment of eczema.METHODS:Sixty-four patients with eczema were randomly divided into trial group with antihuman IL-8 cream and control group with based cream respectively,and then compared the effects outcoming in the clinical application.Antihuman IL-8 cream or based cream was smeared twice daily for 3 wk correspondingly to the designated group.RESULTS:The curative rates and the efficacy rates of trial group and control group were 25% and 3%,47% and 9%,respectively.There were significant statistical dif- ferences between trial and control groups(P＜0.05)in clinical efficacy.No statistical difference in the incidence of adverse reactions between the two groups(P＞0.05).CONCLUSION:Antihuman IL-8 cream is an effective and safe drug in treatment of eczema.