| CD44v6在胃癌胃镜标本和术后标本中的表达及与胃癌生物学行为的关系 |
| |
| 引用本文： | 张大伟,张锦红. CD44v6在胃癌胃镜标本和术后标本中的表达及与胃癌生物学行为的关系[J]. 世界华人消化杂志, 2010, 18(6) |
| |
| 作者姓名： | 张大伟 张锦红 |
| |
| 作者单位： | 辽宁医学院附属第二医院普通外科,辽宁省锦州市,121001 |
| |
| 摘 要： | 目的:研究CD44v6在胃癌胃镜标本和术后标本中的表达,并分析其与胃癌生物学行为的关系.方法:随机选取辽宁医学院附属第二医院普通外科2004-2009年收治的有详细病例资料的胃癌患者50例,应用免疫组织化学方法检测胃镜标本和术后标本胃组织中CD44v6的表达.结果:CD44v6在胃癌胃镜标本、术后标本和转移淋巴结中的表达率分别为60.00%、64.00%、80.77%.显著高于胃良性病变(P＜0.01);CD44v6在肠型胃癌中的表达率显著高于弥漫型胃癌(75.86% vs 47.62%,P＜0.05).胃癌胃镜和术后标本中CD44v6的表达与胃癌浸润深度,TNM分期和淋巴结转移均有关(P＜0.05).CD44v6在胃癌胃镜标本和术后标本中的总体表达率无显著性差异(P＞0.05);相同临床病理参数,CD44v6在胃癌胃镜标本和术后标本中的表达率无显著性差异(P＞0.05).结论:CD44v6可作为术前预测胃癌的发生、病期进展和转移潜能的辅助生物学指标之一.
|
| 关 键 词： | 胃癌 生物学行为 免疫组织化学 |
Relationship between CD44v6 expression and tumor biological behavior in gastric carcinoma |
| |
| Da-Wei Zhang,Jin-Hong Zhang. Relationship between CD44v6 expression and tumor biological behavior in gastric carcinoma[J]. World Chinese Journal of Digestology, 2010, 18(6) |
| |
| Authors: | Da-Wei Zhang Jin-Hong Zhang |
| |
| Affiliation: | Da-Wei Zhang,Jin-Hong Zhang,Department of General Surgery,the Second Aff iliated Hospital of Liaoning Medical University,Jinzhou 121001,Liaoning Province,China Correspondence to: Da-Wei Zhang,Department of Gen- eral Surgery,the Second Affiliated Hospital of Liaoning Medical University,2-49 Shanghai Road,China. jz.13841677280@163.com Received: 2009-10-30 Revised: 2009-12-20 Accepted: 2009-12-29 Published online: 2010-02-28 |
| |
| Abstract: | AIM: To investigate the expression of CD44v6 in gastric cancer and analyze its relationship with tumor biological behavior. METHODS: Fifty patients with gastric carcinoma, who were treated at the Second Affili-ated Hospital of Liaoning Medical University between 2004 and 2009 and had detailed patho-logical data, were included in the study. The expression of CD44v6 in operative and gastro-scopic samples collected from these patients was detected by immunohistochemistry using the streptavidin-peroxidase metho... |
| |
| Keywords: | CD44v6 |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
