Effect of the γ-aminobytyric acid derivative TZ-50-2 on systemic and cardiac hemodynamics and size of myocardial necrosis |
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| Authors: | P. A. Galenko-Yaroshevskii O. S. Medvedev A. V. Uvarov A. N. Mingalev A. Yu. Turovaya Z. I. Tyukhteneva |
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| Affiliation: | (1) Department of Pharmacology, Kuban State Medical Academy, Krasnodar;(2) Laboratory of Pharmacology, Research and Production Cardiology Complex, Ministry of Health of Russia, Moscow |
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| Abstract: | The linear derivative of γ-aminobutyric acid TZ-50-2 (4-hydroxy-3-benzylamino-N-benzyl-butanamide hemisuccinate) stimulates coronary circulation (particularly in the left ventricular myocardium) in intact cats, decreases vascular resistance, stimulates the blood flow in ischemic endo- and mesocardium, and decreases (similarly as perlinganite, obsidan, and finoptin) the necrotic zone area in experimental myocardial infarction. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 12, pp. 662–665, December, 1998 |
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| Keywords: | γ -aminobutyric acid cardiohemodynamics ischemia myocardial infarction |
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