Synthesis and antioxidant activity of 3,5-dimethyl-4-hydroxybenzylthiododecane |
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| Authors: | M. B. Plotnikov A. E. Prosenko V. I. Smol’yakova I. S. Ivanov G. A. Chernysheva N. V. Kandalintseva |
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| Affiliation: | (1) State Institute of Pharmacology, Tomsk Scientific Center, Siberian Branch, Russian Academy of Medical Sciences, Tomsk, Russia;(2) Institute of Antioxidant Chemistry, Novosibirsk State Pedagogical University, Novosibirsk, Russia; |
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| Abstract: | The new multifunctional antioxidant 3,5-dimethyl-4-hydroxybenzylthiododecane (DHBD) demonstrated high activity both in vitro and in vivo. Experiments in vitro showed that the antioxidant activity of DHBD significantly exceeded that of the well-known reference drug ionol. A course of DHBD administration (100 mg/kg, p.o.) significantly decreased the content of lipid peroxidation products in rat brain on the model of long-term incomplete cerebral ischemia. |
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