Bisphosphonates and osteoporotic fractures: a cross-design synthesis of results among compliant/persistent postmenopausal women in clinical practice versus randomized controlled trials |
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| Authors: | M M Wilkes R J Navickis W W Chan E M Lewiecki |
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| Institution: | (1) Hygeia Associates, 17988 Brewer Rd, Grass Valley, CA 95949, USA;(2) Evidence Based Medicine, Novartis Pharmaceuticals Corp, East Hanover, NJ, USA;(3) New Mexico Clinical Research & Osteoporosis Center, Albuquerque, NM, USA |
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| Abstract: | Summary In a cross-design synthesis, total fractures were similarly reduced by bisphosphonates among postmenopausal women in randomized
trials (23.8%) and highly compliant/persistent patients in observational studies of large databases from routine practice
(20.3%). Bisphosphonates also reduced nonvertebral, vertebral and hip fractures in randomized trials and observational studies.
In the real-word setting, compliant/persistent patients can gain a benefit from bisphosphonates comparable to that of randomized
trial participants. |
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