吸入伊洛前列素对海拔5200m青年脑体-心理生理能力的影响

目的探讨伊洛前列素吸入剂对初入海拔5 200 m地区青年脑体-心理生理能力的影响。方法将32名受试者随机分为伊洛前列素组（n=16）和对照组（n=16）,自海拔1 400 m历时5 d进入5 200 m,从进入海拔5 200 m当天开始,伊洛前列素组每天4次雾化吸入伊洛前列素溶液,连续5 d。对照组用同样的方法雾化吸入生理盐水。于吸入伊洛前列素溶液第5天采用DDX-200型电脑多功能心理生理测试仪,进行脑体-心理生理能力检测。检测项目包括左右手交叉敲击和缺失记忆的简单测验。结果伊洛前列素组与对照组比较,左右手交叉敲击：总时间均为（10±0）s,总次数为（87.24±17.67）与（72.92±15.38）次,正确次数为（85.06±15.18）与（71.19±14.81）次,错误次数为（1.47±0.74）与（2.96±2.01）次;缺失记忆的简单测验结果：总次数均为（17±0）次,错误次数为（1.72±0.88）与（2.96±2.01）次。差异均有统计学意义（P〈0.05）。结论在高原雾化吸入伊洛前列素溶液能显著提高移居者的脑体-心理生理功能,可以促进高原习服、预防和治疗急性高原病。

Effect of inhaling Iloprost on brain-body mental-physiology capability of young people at 5200m high altitude

Objective To explore the effect of inhaling Iloprost on brain-body mental-physiology capability of young people exposed to 5 200m high altitude.Methods 32 subjects who reached 5 200m altitude from 1 400m altitude were divided into two groups： 16 in experiment group and 16 in control group.After they reached 5 200m altitude,experiment group inhaled one dose Iloprost and control group atomization inhaled physiological saline four times daily for 5 days.The brain-body mental-physiology capability detection such as both-hands-cross frequency and depl-memory test were performed by type DDX-200 multifunction psychological machine.Results There were comparisons between experiment group and control group.Both-hands-cross frequency： the cumulative time were all（10±0）s,total numbers were（87.24±17.67）times and（72.92±15.38）times,correct numbers were（85.06±15.18）times and（71.19±14.81）times,wrong numbers were（1.47±0.74）times and（2.96±2.01）times.Depl-memory test： the total numbers were（17±0）times,wrong numbers were（1.72±0.88）times and（2.96±2.01）times,the differences showed statistical significance（P〈0.05）.Conclusion Iloprost can improve brain-body mental-physiology capability and altitude acclimatization,prevent and treat acute mountain reaction at high altitude.