| 补阳还五汤对实验性脑缺血大鼠水通道蛋白-4表达的影响 |
| |
| 引用本文： | 杜志刚,王艳玲. 补阳还五汤对实验性脑缺血大鼠水通道蛋白-4表达的影响[J]. 世界科学技术, 2008, 10(1): 72-75 |
| |
| 作者姓名： | 杜志刚 王艳玲 |
| |
| 作者单位： | 华北煤炭医学院附属医院,唐山063000 |
| |
| 基金项目： | 河北省中医药管理局科学研究计划 |
| |
| 摘 要： | 目的：观察补阳还五汤对大鼠脑缺血后AQP-4表达和患肢恢复功能的影响。方法：100只SD大鼠分为损伤组和中药组,均手术致脑缺血。中药组术后即给予补阳还五汤口服液灌胃;损伤组给予等量蒸馏水灌胃。术后1、3、7、14及21天分别对大鼠进行BBB评分和斜板实验检查患肢功能,然后处死,应用免疫组织化学技术检测脑组织AQP-4的表达。结果：脑缺血后第1天,两组受损伤脑灰质、白质中可见到AQP-4的表达明显增加;第3天时达到高峰,损伤组更明显（P〈0.05）;第7、14及21天,中药组AQP-4表达的减少几乎与神经功能的改善平行,与损伤组比较差异有非常显著性（P〈0.01）。结论：补阳还五汤可能通过抑制脑缺血后AQP-4表达,消除脑水肿,减轻脑损伤,从而使残存脑组织保存并促进肢体功能恢复。
|
| 关 键 词： | 补阳还五汤 大鼠 实验性脑缺血 水通道蛋白-4 |
Effects of Buyanghuanwu Tang Formula on AQP-4 of Rats with Experimental Ischemic Brain |
| |
| Du Zhigang Wang Yanling Hospital Affiliated to North China Medical Institute for Coal Industry,Tangshan,Hebei. Effects of Buyanghuanwu Tang Formula on AQP-4 of Rats with Experimental Ischemic Brain[J]. World Science and Technology(Modernization of Traditional Chinese Medicine), 2008, 10(1): 72-75 |
| |
| Authors: | Du Zhigang Wang Yanling Hospital Affiliated to North China Medical Institute for Coal Industry Tangshan Hebei |
| |
| Affiliation: | Du Zhigang Wang Yanling Hospital Affiliated to North China Medical Institute for Coal Industry,Tangshan,Hebei,063000 |
| |
| Abstract: | We investigated the effects of Buyanghuanwu Tang formula on AQP-4 expression in ischemic rats' brain, and associated functional recovery of limbs. In the study, 100 SD rats with incomplete ischemic brain were divided into injury group and traditional Chinese medicine group. The TCM group received Buyanghuanwu Tang formula after operation, and the injury group are fed with distilled water. BBB scale and inclined plane tests were performed to see the functionality of the limbs. The animals were sacrificed 1, ... |
| |
| Keywords: | Buyanghuanwu Tang formula rats experimental ischemic brain aquaporin-4 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
