| 三硝基甲苯和4—氨基—2,6—二硝基甲苯对小鼠睾丸染色体畸变率的影响 |
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| 引用本文： | 李斌,吴琼.三硝基甲苯和4—氨基—2,6—二硝基甲苯对小鼠睾丸染色体畸变率的影响[J].工业卫生与职业病,1997,23(1):24-27. |
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| 作者姓名： | 李斌 吴琼 |
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| 作者单位： | 兵器工业卫生研究所!西安丈八东路1号，710065 |
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| 摘 要： | 实验观察了三硝基甲苯１０、５０和１００ｍｇ／ｋｇ剂量及４－氨基－２，６－二硝基甲苯５０、１００和２００ｍｇ／ｋｇ剂量对６１５小鼠睾丸初级精母细胞染色体畸变率的影响，实验结果显示，ＴＮＴ和４－Ａ诱发小鼠睾丸初级精母细胞染色体与畸变率明显增高，呈剂量效应关系。表明它们都是性细胞染色体的诱变物，而且４－Ａ的诱发活性与ＴＮＴ相近。
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| 关 键 词： | 三硝基甲苯 二硝基甲苯 染色体畸变 |
EFFECT OF TNT AND 4-AMINO-2,6-DINITROTOLUENE(4-A)ON CHROMOSOME ABERRATION RATE IN TESTICLE OF MICE |
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| Li Bin et al.EFFECT OF TNT AND 4-AMINO-2,6-DINITROTOLUENE(4-A)ON CHROMOSOME ABERRATION RATE IN TESTICLE OF MICE[J].Industrial Health and Occupational Diseases,1997,23(1):24-27. |
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| Authors: | Li Bin |
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| Abstract: | The mutagenicity of TNT and 4-A has been detected with chromosome aberration assay in primary spermatocyte of mouse testicle. The results showed that TNT and 4-A could induce remarkable increase of chromosome aberration rate at doses of 10, 50, 100mg/kg and 50, 100, 200 mg/kg respectively with significant difference (P<0. 01 )when compared with negative controls. A doseeffect relationship clearly existed. It indicates that TNT and 4-A are both mutagenic to chromosome of sexual cells and the mutagenicity of 4-A is similar to that of TNT. |
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| Keywords: | Trinitrotoluene (TNT) 4-Amino-2 6-dinitrotoluene (4-A) Primary spermatocyte Chromosome aberration |
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