胃癌早期诊断的相关分子生物学指标

探讨了增殖细胞核抗原（PCNA）、p53、端粒酶、ras蛋白等作为胃癌早期诊断分子生物学指标的可能性。通过对献的分析。发现PCNA、p53是胃癌早期诊断应当首先考虑的分子生物学指标。它们可用简单的免疫组化方法方便地测得，端粒酶也是一个很好的指标。只是由于其检测方法不够方便，价格较贵，故可行性不如前两个指标。此外，ras也可以考虑作为胃癌早期诊断的辅助指标。

Molecular biological markers on diagnosis of early gastric cancer

Gastric cancer(GC) is deeply threatening the health of our people, the mortality rate of GC is the second death cause of carcinoma i n our country. Since the lack of special clinical symptom at the early state of GC, detecting GC at the molecular biological level is expected to diagnose early gastric cancer. This article discusses some markers such as PCNA, p53, telomera se, ras protein and so on to assess the possibility of diagnosing the early gas tric cancer with these molecular biological markers. According to analyzing rela ted papers published, PCNA and p53 were found to be the molecular biological mar kers which should be firstly taken into account in diagnosing gastric cancer. Bo th of them can be easily detected by using immunohistochemical method. Telomeras e is also a good marker, but because of its difficult technology and high cost, it is not so practicable as the former two as the diagnostic marker of early gas tric cancer. Besides, ras potein can also be taken into account as the early det ecting auxiliary marker for GC.