Non-small-cell lung cancer associated with non-thymomatous myasthenia gravis |
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Authors: | Yasushi Sakamaki Hyung-Eun Yoon and Naofumi Oda |
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Institution: | (1) Department of General Thoracic Surgery, Rinku General Medical Center, Izumisano, Osaka, Japan;(2) Present address: Department of General Thoracic Surgery, Rinku General Medical Center, 2-23 Rinku-orai-kita, Izumisano, 598-8577 Osaka, Japan |
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Abstract: | A non-small-cell lung cancer without distant metastases was incidentally found in a 77-year-old man who had suffered from
myasthenia gravis (MG) without thymoma. The patient’s condition was stabilized by oral pyridostigmine bromide which he had
taken during the past 6 years. He simultaneously underwent thymectomy and left lower lobectomy with regional lymph node dissection.
Although postoperative myasthenic crisis occurred, mechanical ventilation and intravenous steroid pulse relieved the patient
and the symptoms improved thereafter. Cases of operable lung cancer with non-thymomatous MG have rarely been reported and
the appropriate therapeutic strategy for such cases remains to be debated. Their causal association remains to be identified,
whereas some studies have implied that immune disorder due to the abnormal thymus might possibly enhance the oncogenesis of
extrathymic malignancies. Myasthenic crisis should also be taken into account in postoperative management of MG patients who
simultaneously undergo thymectomy and lobectomy for synchronous lung cancer. |
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Keywords: | myasthenia gravis lung cancer thymectomy pulmonary lobectomy Myasthenic crisis |
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