Immunohistochemical study on the distribution of canonical transient receptor potential channels in rat basal ganglia |
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| Authors: | Yoon Hee Chung Daejin Kim Nam Joo Moon Chang Seok Oh Eunju Lee Dong Hoon Shin Sung Su Kim Won Bok Lee Jun-Young Lee Choong Ik Cha |
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| Affiliation: | 1. Department of Anatomy, College of Medicine, Chung-Ang University, 221 Heukseok-Dong, Dongjak-Gu, Seoul 156-756, South Korea;2. Department of Ophthalmology, College of Medicine, Chung-Ang University, 221 Heukseok-Dong, Dongjak-Gu, Seoul 156-756, South Korea;3. Department of Internal Medicine, Asan Medical Center, University of Ulsan, College of Medicine, 388-1 Poong-Nap Dong, Song-Pa Gu, Seoul 138-736, South Korea;4. Department of Anatomy, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, Seoul 110-799, South Korea;5. Department of Psychiatry, Seoul National University College of Medicine, Boramae Hospital, 425 Shindaebang 2-Dong, Dongjak-Gu, Seoul 156-707, South Korea;6. Biomedical Brain Research Center, KNIH, Seoul, South Korea |
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| Abstract: | In the present study, we examined the localizations of canonical transient receptor potential channels (TRPCs) in rat basal ganglia. The dot-like staining pattern of TRPC5 was observed through the globus pallidus (GP) and caudate-putamen. TRPC7 had a strikingly high level of expression in the neuropil in the GP. In the subthalamic nucleus, strong staining for TRPC5 was observed in the cell bodies, while moderate to high immunoreactivies for TRPC1, TRPC3, TRPC4 and TRPC7 were found in the cell bodies and surrounding neuropil. In the substantia nigra, immunoreactivities for TRPC3 and TRPC7 were prominent in the cell bodies and several processes in the pars compacta and pars reticulata. TRPC6 was expressed in the neuropil, not in the cell bodies. This study may provide useful data for the future investigations on the structural and functional properties of TRPCs. |
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| Keywords: | Transient receptor potential (TRP) channels TRPC Rat Basal ganglia Immunohistochemistry Parkinson's disease (PD) |
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