有氧运动对冠心病患者内皮功能的影响

目的：观察有氧运动对冠心病患者内皮功能的影响。方法：入选60例平时缺乏运动的冠心病患者,随机均分为运动干预组和药物治疗组,运动干预组进行有氧运动,每周5次,每次30 min。药物治疗组给予美托洛尔、硝酸甘油等药物治疗。各组干预12周,干预前后采用酶联免疫吸附试验法测定血清细胞间粘附分子-1（ICAM-1）和白介素-18（IL-18）水平,酶法测定一氧化氮（NO）水平。另选20例健康体检者作为正常对照组。结果：与健康人比较,冠心病患者血清ICAM-1[（246.43±39.32）ng/ml比（335.03±61.99）ng/ml]和IL-18[（230.60±29.15）pg/ml比（308.67±48.08）pg/ml]水平明显升高,NO[（80.34±13.22）μmol/L比（48.54±7.64）μmol/L]水平明显降低（P均〈0.01）。与治疗前比较,经12周运动干预后,ICAM-1[（333.47±57.29）ng/ml比（304.66±45.58）ng/ml]和IL-18[（310.82±47.37）pg/ml比（290.18±38.47）pg/ml]水平明显下降,NO[（49.88±7.90）μmol/L比（54.00±8.83）μmol/L]水平明显升高（P〈0.05）。运动干预与药物治疗效果相当（P〉0.05）。结论：长期规律有氧运动能够显著改善冠心病患者的内皮功能。

Effects of aerobic exercise on endothelial function in patients with coronary heart disease

Objective:To explore the effects of aerobic exercise on endothelial function in patients with coronary heart disease(CHD).Methods:A total of 60 CHD patients lacked of exercises were randomly and equally divided into exercise intervention group(performed aerobic exercise,30 min 5 times/week) and medicinal treatment group(received medicinal treatment with metoprolol and nitroglycerol).Both groups were treated for 12 weeks.Enzyme linked immunosorbent assay was used to measure serum levels of intercellular adhe...