急性心肌梗死患者血清炎症因子、尿酸水平的变化

目的：观察急性心肌梗死（AMI）患者血清白细胞介素（IL）-6、IL-10、C反应蛋白（CRP）、血尿酸（SUA）浓度的变化,探讨上述因子对AMI的影响。方法：选择AMI患者（AMI组）30例和正常人30例（正常对照组）做对照研究。正常对照组于清晨空腹抽取静脉血,AMI组分别于发病后24h、2周抽取静脉血6ml。检测所有研究对象血清炎症因子,SUA等水平。结果：与正常对照组比较,AMI组发病24h后血清IL-6[（114.66±25.74）pg/ml比（238.11±102.08）pg/ml]、IL-10[（17.68±3.33）ng/ml比（22.84±12.36）ng/ml]、CRP[（3.27±1.25）mg/L比（24.51±19.46）mg/L]、SUA[（252.76±50.70）μmol/L比（379.50±122.90）μmol/L]、IL-6/IL-10比值[（6.70±1.99）比（13.94±10.03）]水平明显升高（P〈0.05～0.01）。结论：急性心肌梗死时血清白细胞介素6、10,C反应蛋白、血尿酸水平明显升高,它们共同参与了急性心肌梗死的发生和发展。

Changes of serum levels of inflammatory factors and uric acid in patients with acute myocardial infarction

Objective：To investigate changes of serum concentrations of interleukin-6（IL-6）,IL-10,C-reactive protein（CRP） and uric acid（SUA） in patients with acute myocardial infarction（AMI） and explore effects of above factors on AMI.Methods：A total of 30 AMI patients（AMI group） and 30 healthy people（normal control group） were enrolled in the study.Serum concentrations of inflammatory factors and SUA of all cases were detected.Results：Compared with normal control group,serum levels of IL-6 [（114.66±25.74） pg/ml vs.（238.11±102.08） pg/ml],IL-10 [（17.68±3.33） ng/ml vs.（22.84±12.36） ng/ml],CRP [（3.27±1.25） mg/L vs.（24.51±19.46） mg/L],SUA [（252.76±50.70） μmol/L vs.（379.50±122.90） μmol/L] and ratio of IL-6/IL-10 [（6.70±1.99） vs.（13.94±10.03）] significantly increased on 24h after onset in AMI group（P〈0.05～0.01）.Conclusion：Serum levels of interleukin-6,10,C-reactive protein and uric acid significantly increase at the onset of acute myocardial infarction.All of above parameters may be take part in the incidence and development of acute myocardial infarction.