Primary rhabdoid tumour of the brain |
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| Authors: | S. M. Jakate H. B. Marsden L. Ingram |
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| Affiliation: | (1) Department of Pathology and Oncology, Royal Manchester Children's Hospital, M27 1HA Pendleburgy, Manchester, UK;(2) Department of Pathology, University of Leeds, LS2 9JT Leeds, UK |
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| Abstract: | Summary A posterior fossa tumour in a 3 year old child is presented with characteristic histological, ultrastructural and immunohistochemical features of rhabdoid tumour. Many tumour cells contained cytoplasmic eosinophilic hyaline inclusions. Ultrastructurally concentric whorls of 10 nm intermediate filaments were identified. Immunohistochemical staining disclosed vimentin, cytokeratin and epithelial membrane antigen positivity. Renal and extrarenal rhabdoid tumours have been well documented but a primary rhabdoid tumour of the brain is extremely rare. Additional ultrastructural features seen were tubular crystalline inclusions in endoplasmic reticulum and abnormal large mitochondria. |
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| Keywords: | Rhabdoid tumours Primary brain tumours Intermediate filaments Wilms' and related tumours Vimentin |
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