Favorable prognostic value of SOCS2 and IGF-I in breast cancer |
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| Authors: | Michael C Haffner Barbara Petridou Jean Phillipe Peyrat Françoise Révillion Elisabeth Müller-Holzner Günter Daxenbichler Christian Marth Wolfgang Doppler |
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| Affiliation: | 1.Division of Medical Biochemistry, Biocenter,Innsbruck Medical University,Innsbruck,Austria;2.Unité GPL, INRA,Jouy-en-Josas Cedex,France;3.Centre Oscar Lambret,Lille Cedex,France;4.Department of Obstetrics and Gynecology,University of Innsbruck,Innsbruck,Austria |
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| Abstract: | Background Suppressor of cytokine signaling (SOCS) proteins comprise a protein family, which has initially been described as STAT induced inhibitors of the Jak/Stat pathway. Recent in vivo and in vitro studies suggest that SOCS proteins are also implicated in cancer. The STAT5 induced IGF-I acts as an endocrine and para/autocrine growth and differentiation factor in mammary gland development. Whereas high levels of circulating IGF-I have been associated with increased cancer risk, the role of autocrine acting IGF-I is less clear. The present study is aimed to elucidate the clinicopathological features associated with SOCS1, SOCS2, SOCS3, CIS and IGF-I expression in breast cancer. |
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