Monocrotaline-induced structural remodeling of the intra-acinar pulmonary arteries and pulmonary hypertension |
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Authors: | Li Wen-ying Che Dong-yuan |
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Institution: | (1) Department of Pathology, Tongji Medical University, Wuhan |
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Abstract: | Summary The monocrofaline-induced structural changes of small pulmonary arteries in rat and their relationship with pulmonary hypertension
and right ventricular hypertrophy were observed by determining the right ventricular systolic pressure, and by light and electron
microscope and morphometry. One to 38 days after last injection of monocrotaline (MCT), a medial thickening and lumen marrrowing
of the circular muscular arteries (CMA), accompanying terminal (TB) and respiratory bronchioles (RB), were found. And there
after the lumen of CMA, accompanying TB, became dilated, and its medial thickness (MT) decreased, whereas the histopathologic
changes of the partially muscular arteries (PMA), accompanying RB, became severe, their MT increased continuously, and finally
reached the peak value on Day 50. At the first day after last MCT treatment, inflammation and muscularization were found in
PMA and nonmuscular arteries (NMA), and became more severe with the cause of disease. Therefore, the intra-acinar pulmonary
arteries, both CMA and PMA, increased in number while the NMA decreased in number significantly because of the structural
remodeling. Four days after MCT treatment, the right ventricular systolic pressure began to rise, and reached its peak value
on Day 50. Eight days after MCT injection, right ventricular hypertrophy developed, and became most significant from Day 23
to Day 30. The results suggest that structural remodeling, i.e. muscularization, of intra-acinar pulmonary arteries plays
an important role in the development of pulmonary hypertension and right ventricular hypertrophy. |
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Keywords: | monocrotaline intra-acinar pulmonary artery muscularization hypertension |
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