HBsAg携带者其配偶HBV血清学标志物感染情况调查分析

目的　研究男、女 HBs Ag携带者其配偶经性传播感染 HBV情况。　方法　采用 EL ISA法 ,分别于婚后第 1、3、5年检测 HBV感染者的配偶血液中乙肝五项血清学标志物。　结果　男性为 HBs Ag携带者其配偶婚后 1、3、5年 HB-s Ag阳转率分别为 30 %、4 4 %、5 8% ;而女性为 HBs Ag携带者其配偶婚后 1、3、5年 HBs Ag阳转率为 10 %、18%、2 6 % ;两组间配偶 HBs Ag阳转率的差别有显著性 (P分别 <0 .0 5、0 .0 1、0 .0 1)。同时 ,男性为 HBs Ag携带者伴有 HBe Ag阳性者 ,婚后其配偶三次追踪检测 HBV感染率分别为 5 2 .6 %、73.7%、78.9% ;而女性为 HBs Ag携带者伴有 HBe Ag阳性者 ,婚后其配偶三次追踪检测 HBV感染率分别为 17.6 %、35 .3%、4 7.1% ,同样两组间有显著性差异 (P均 <0 .0 5 )。　结论　男性为 HBs Ag携带者 ,HBV传播给配偶的机率要显著大于女性 HBs Ag携带者传播给配偶的机率。伴有 HBe Ag阳性者要比仅 HBs Ag阳性者传播给配偶的机率要高。

The Investigation and Analysis on the Infectious Conditions of Five HBV Serological Markers of HBsAg Carriers'''' Spouses

Objective To study sexual transmitted HBV infectious conditions of males and females whose spouses are HBsAg carriers and provide basis for the prevention of infection of HBV between spouses. Methods With ELISA, five serologic markers of hepatitis B in the blood of spouses of those infected by HBV were separately examined in the first, third and fifth year after their marriage. Result The HBV infectious rates of male HBsAg carriers' spouses were 38%, 60% and 80% in the three follow-up examinations after their marriage and the positive rates of HBsAg were 30%, 44% and 58%, while those of female HBsAg carriers' spouses were 18%, 30% and 44% and positive rates of HBsAg were 10%, 18% and 26%. So there were remarkable differences in the total HBV infectious rates between the two groups (P<0.05, P<0.01, P<0.01, respectively). Meanwhile, if male HBsAg carriers were accompanied by HBeAg-positive, the HBV infectious rates of males' spouses are 52.6%, 73.7% and 78.9% in the three follow-up examinations after their marriage. While those of female HBsAg carriers accompanied by HBeAg-positive were 17.6%, 35.3% and 47.1%. Similarly, there were remarkable differences between the two groups (P<0.05 in all). Conclusion If males are HBsAg carriers, their spouses' infectious chance is much greater than that of females'. If HBsAg carriers are accompanied by HBsAg-positive, their spouses' infectious chance is much greater than that of those only infected by HBsAg-positive. Anti-HBs is effective to protect people from HBV infection.