宁泌泰胶囊联合抗生素治疗慢性前列腺炎的Meta分析

为评价宁泌泰胶囊联合抗生素治疗慢性前列腺炎是否比单纯抗生素治疗更加安全有效,检索了中国期刊全文数据库(CNKI)、中国优秀硕士/博士学位论文数据库、万方数据库、维普中文科技期刊数据库(VIP)以及Medline和EMBASE,选取了所有自2000——2013年发表的有关宁泌泰胶囊联合抗生素治疗慢性前列腺炎的研究文献,按Cochrane系统评价方法进行筛选,采用Stata 12.0软件对治疗效果、慢性前列腺症状指数量表(NIH-CPSI)以及前列腺按摩液镜检白细胞(EPS-WBC)计数进行Meta分析。共纳入11篇随机对照试验(RCT)文献,总样本量达2 079例。分析结果显示,宁泌泰胶囊联合抗生素治疗慢性前列腺炎与单用抗生素治疗相比,治疗效果显著改善[OR=2.47,95%CI(2.08,2.93)],NIH-CPSI总分显著降低[WMD=-8.14,95%CI(-9.39,-6.90)],EPS-WBC计数显著减少[WMD=-6.14,95%CI(-8.11,-4.17)]。宁泌泰胶囊可以明显改善抗生素治疗慢性前列腺炎的疗效和NIH-CPSI、EPS-WBC等相关指标,为改善临床治疗方案提供了一定的参考。

Meta-analysis on Ningmitai Capsule combined with antibiotics therapy for chronic prostatitis

To evaluate if Ningmitai Capsule combined with antibiotics therapy is safer and more effective than simple antibiotics therapy for chronic prostatitis, we firstly retrieved the China journal full-text database (CNKI), China's outstanding master's/doctoral dissertation database, Wan Fang database, VIP science and technology periodical database, MEDLINE, and EMBASE. Secondly, we selected research literatures from 2000 to 2013 on Ningmitai Capsule combined with antibiotics therapy for chronic prostatitis. Then, the data were filtered by Cochrane system evaluation method and conducted for Meta-analysis on the effectiveness, chronic prostatitis symptoms index (NIH-CPSI) and microscopy count of white blood cell in expressed prostatic secretion (EPS-WBC) via Stata 12.0 software. Finally, 11 articles including 2 079 samples were totally involved. The Meta-analysis results showed that compared with simple antibiotics treatment, Ningmitai Capsule combined with antibiotics therapy significantly increased the cure rate [OR = 2.47, 95% CI (2.08, 2.93)] and lowered NIH-CPSI [WMD = -8.14, 95% CI (-9.39, -6.90)] as well as EPS-WBC [WMD = -6.14, 95% CI (-8.11, -4.17)]. So the study suggests that Ningmitai Capsule can significantly improve the cure rate and related indicators of simple antibiotics therapy for chronic prostatitis, which provides certain references for improving clinical treatment.